Since the evidence on the contribution of pathogenic variants in mismatch repair genes for breast cancer is not very strong, it is more likely that the LPath variant in BRCA2 plays a crucial role in the development of familial breast cancer, and the involvement of the variant p.His318Gln in the MLH1 gene in the patient’s breast cancer may be marginal or limited. Here, MLH1 is linked to breast carcinoma.