Consistent with upregulation of Piezo1 proteins in diseased mouse and rat hearts (Fig. 8a)34, RT-PCR revealed a 5-fold increase in the mRNA expression of Piezo1 in human heart samples with hypertrophic cardiomyopathy compared to normal heart samples (Fig. 8b and Supplementary Excel Sheet). Here, PIEZO1 is linked to hypertrophic cardiomyopathy.