The lack of statistical significance is likely due to the small sample size (i.e., the same proportions of 17/31 pCR in PD-L1 positive and 6/19 pCR in PD-L1 negative cancers would have resulted in a p < 0.0001 in a 500-patient trial [corresponding numbers would be 170/310 and 60/190]). Here, CD274 is linked to cancer.