C9 and amyotrophic lateral sclerosis: Others have reported that 2′-O-methyl (2′-OMe)-25 or 2′-O-(2-methoxyethyl) (2′-MOE)-modified8,11 oligonucleotides targeting the G4C2 expansion in C9orf72 can selectively deplete expansion-containing transcripts in models for C9-ALS/FTD.