C9orf72 and amyotrophic lateral sclerosis: C9orf72-630 (IC50 = 876.9 nM) and C9orf72-631 (IC50 = 394.2 nM) dose-dependently knocked down V3 transcripts in ALS motor neurons (Fig. 2c, left) and were preferentially active against V3 compared with all variants at all concentrations tested (Fig. 2c, right).