Based on the summary SHAP plots, we observed that among the top 10 pathways affecting survival in EA patients, the majority displayed an inverse correlation of enrichment with survival, including barrier genes, reactive oxygen species pathway, EGF signaling, hedgehog signaling, UVC-induced MAPK signaling, AMPK signaling, estrogen-dependent breast cancer signaling, and UV response up genes (Fig. 4b). This evidence concerns the gene EGF and Esophageal atresia.