MAPK3 and brain neoplasm: ERK1/2 activation by lindane in sertoli cells was reported to prevent autophagosome maturation and targeted inhibition of Ras-Raf-MEK-ERK pathways in PDAC cells bearing activating mutation in Ras or Raf, or in BRAFi resistant brain tumor cells, was known to induce autophagic flux45–47.