Gene expression of the fructose-specific transporter, Glut5, and fructose metabolizing enzyme, Fructokinase-A (also termed ketohexokinase-A, phosphorylates fructose to fructose-1-phosphate), were evaluated in T2D rat hearts (Zucker Diabetic Fatty (ZDF) rat). This evidence concerns the gene SLC2A5 and diabetes mellitus.