IFNA2 and malignant pleural mesothelioma: Intrapleural administration of Ad-delivered interferon (IFN)-β or IFN-α-2b to the lungs have been proven to be safe treatments for malignant pleural mesothelioma.94,95 Most recently, treatments using Ad-IFN-α-2b in combination with celecoxib and gemcitabine are being actively tested in a phase III trial (NCT03710876).