CBS and chronic myelogenous leukemia, BCR-ABL1 positive: These signaling pathways promote the cell survival and cell adhesion of hematopoietic stem cells, leading to form CML abnormal clones.5,34,35 To determine whether inhibition of CBS affects BCR-ABL expression or its phosphorylation, and the downstream PI3K/AKT, MAPK, ERK signaling pathways, Western blot analysis was performed to detect the phosphorylation levels of related proteins in the cells treated with different concentrations of AOAA or transfected with shRNA.