CDK6 and leukemia: We further detected the mRNA levels of NF-κB-regulated genes including WT1, STAT5a, CDK6, and VIM, which play important roles in the development of leukemia.36,38–41 AOAA treatment (Fig. 7b) or shRNA transfection (Fig. 7c) significantly reduced the mRNA levels of these genes (P < 0.05).