CBS and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, CML-derived K562 cells showed significantly higher CBS expression than that in human CD34+ umbilical cord hematopoietic stem cells as the control (1.00 ± 0.39 vs. 4.97 ± 0.74, P = 0.0077), while the expressions of CSE and 3-MST did not have significant changes (Fig. 1e).