Finally, except for the known driver genes of HCC, five new driver genes of HCC, including MAP4K3, COX5B, ACTN3, CFTR, and LRRC7, were associated with the early recurrence of HCC (recurrence within 6 months) and 2 genes, PRKCG and SENP3, were considered new driver genes associated with the late recurrence of HCC (recurrence after 1 year) (P < 0.005, false discovery rate (FDR) ≤ 0.1, Table 3). This evidence concerns the gene ACTN3 and hepatocellular carcinoma.