To further identify the representative genes associated with HCC prognosis, alterations in the five most frequently mutated genes (TP53, CTNNB1, KMT2C, ARID1A, and PCLO) were detected between groups A and B. CTNNB1, KMT2C, ARID1A, and PCLO were significantly associated with HCC prognosis (likelihood ratio P = 0.018 for CTNNB1 and likelihood ratio P = 0.03 for KMT2C, ARID1A, and PCLO; Table 2). Here, TP53 is linked to hepatocellular carcinoma.