As described above WES and comparative analysis identified 11 novel genes (KMT2C, ARID1A, NBPF10, CSMD1, MAP4K3, COX5B, ACTN3, CFTR, LRRC7, PRKCG, and SENP3) that were significantly associated with HCC in our Chinese population. The gene discussed is ARID1A; the disease is hepatocellular carcinoma.