In ovarian cancer cells, knockdown of CDT2 but not DCAF1 phenocopies the effects of MLN4924, and silencing of CDT1 partially rescues apoptotic death induced by MLN4924 [16], while the pharmacological effect of MLN4924 is independent of p21 or SET8 [14], indicating special role of CDT2 and CDT1 in cancer development. The gene discussed is DTL; the disease is ovarian carcinoma.