Moreover, there are several reports where mutations in the CaV2.1 gene (CACNA1A) cause several autosomal-dominant neurological disorders including familial hemiplegic migraine type 1, and cerebellar pathologies such as ataxia, progressive ataxia and early-onset cerebellar syndrome [13, 14]. This evidence concerns the gene CACNA1A and familial or sporadic hemiplegic migraine.