Although amyloid deposition is indiscriminate and therefore may affect any part of the body, the most prevalent areas leading to distinct pathologies are around the peripheral nerves, resulting in transthyretin amyloid polyneuropathy, or ATTR-PN, and the heart, leading to a related yet different form known as transthyretin amyloid cardiomyopathy, or ATTR-CM [1]. Here, TTR is linked to cutaneous mastocytosis.