Furthermore, increasing evidence suggests that there is plasticity of the nervous system in asthma, reflected by increased excitability of neurons and even outgrowth of neurons [11], as shown recently for sensory and cholinergic neurons in biopsies from asthma patients compared to healthy subjects [12, 13] Furthermore, in asthma, there is increased release of peptide neurotransmitters, e.g. substance P and neurokinin A, which can contribute to neurogenic inflammation [14]. The gene discussed is TAC1; the disease is asthma.