The A-to-I editing of NUP43 (Diff = − 0.33; p = 8.0 × 10− 6) and KCNE3 (Diff = − 0.15; p = 0.0026) is associated with shorter survival time of CRC patients (Fig. 5e; NUP43: log-rank test, p = 0.024; KCNE3: log-rank test, p = 0.0077). The gene discussed is NUP43; the disease is colorectal carcinoma.