In our current study, the relationship between reduction of inflammatory response by MAR1 and SIRT1/PGC-1α/PPAR-γ signaling axis was systematically investigated and intended to explain the specific mechanism of MAR1 in in vitro sepsis models of LPS-induced RAW 264.7 cells and human primary peripheral blood mononuclear cells (hPBMCs). The gene discussed is PPARG; the disease is Sepsis.