Several previous studies found that FKBP10 mutations disrupting the amino acid sequence of FKBP-type3 PPIase domain were a cause of recessive osteogenesis imperfecta and Bruck syndrome [26, 27], which suggested that FKBP-type3 PPIase domain may paly a key role in the biological function of FKBP10. The gene discussed is FKBP10; the disease is osteogenesis imperfecta.