The covariates in Multiple regression model was established according to the univariate regression analysis and clinical significance, and the result showed that after adjusting for age, sex, smoking, and diabetes, serum CRP, cfDNA/NETs, IL-1β, and homocysteine levels remained as independent factors affecting the methylation level of the ABCA1 promoter (Table 5). The gene discussed is CRP; the disease is diabetes mellitus.