Upon considering the study group (pCAD vs. control) as the dependent variable and age, sex, BMI, waist circumference, TG, TC, HDL-C, LDL-C, HbA1c, diabetes, hypertension, and ABCA1 promoter methylation status as the covariates, we identified the methylation level of the ABCA1 promoter (odds ratio (OR) = 2.878, 95% confidence interval (CI) 1.802–4.594; P < 0.001), HDL-C (OR = 0.015, 95% CI 0.004–0.032; P < 0.001), BMI (OR = 1.892, 95% CI 1.374–2.604; P = 0.017) and HbA1c (OR = 3.162, 95% CI 1.148–8.709; P = 0.026) as independent risk factors for pCAD development (Table 4). The gene discussed is ABCA1; the disease is diabetes mellitus.