The downregulated 2-hydroxyisobutyrylated proteins were enriched in 16 processes, including regulation of the actin cytoskeleton, IL-17 signaling pathway, PI3K-Akt signaling pathway, fluid shear stress and atherosclerosis, and ribosome and phagosome, which have important associations with IgAN complications (Fig. 8b). This evidence concerns the gene IL17A and atherosclerosis.