Our data showed that the smokers with XAB2 rs794078 AA genotype had a significantly decreased risk of gastric cancer compared with nonsmokers with GG genotype (OR = 0.11, 95% CI = 0.11–0.91, p = 0.040), suggesting rs794078 AA genotype was a protective factor for gastric cancer in smokers (Table 4). Here, XAB2 is linked to gastric cancer.