We identified HBV integrations with high integration allele fractions in tumors in seven non-recurrent cancer-related genes, including GAS7 [74,75], NSP [76], RSPO2 [77,78], NRG1 [79], PRDM16 [80], ARID1B [81], and AFF1 [82]. The gene discussed is SPECC1; the disease is cancer.