RSPO2 and cancer: Besides the integrations in these three genes, we identified seven HBV integrations with high integration allele fractions in other genes, most of which have been reported to be associated with cancer, including GAS7, SPECC1 (NSP), RSPO2, NRG1, PRDM16, ARID1B, and AFF1, as initially described in our recent method paper [13].