These findings may be explained on a molecular level as Survivin orchestrates NF-κB dependent expression of fibronectin, integrin signaling, activation of focal adhesion kinase (FAK) and Src, and upregulation of v-akt murine thymoma viral oncogene homolog (AKT) pathway to mediate tumor cell migration and metastatic dissemination [109]. This evidence concerns the gene BIRC5 and neoplasm.