According to a report by Krajewska et al., an elevated expression of cIAP2 in stage II CRC cases significantly correlated with an impaired overall survival (OS) in both uni- and multivariate analyses [97] and is considered to be a predictive marker for the sensitivity to the chemotherapeutic drug 5-fluorouracil [98]. The gene discussed is BIRC3; the disease is colorectal carcinoma.