We have recently demonstrated that Tat induces oxidative stress and DNA damage in peripheral blood lymphocytes [15], and induces repositioning of the MYC locus on chromosome 8 in the close proximity to the IGH locus on the chromosome 14, thereby increasing the chances of the oncogenic translocation t (8;14) characteristic of Burkitt lymphomas [12]. The gene discussed is MYC; the disease is Burkitt lymphoma.