Recently, recurrent mutations affecting KRAS and PIK3CA have been reported in ovarian endometriosis, deep infiltrative endometriosis, uterine adenomyosis, normal endometrium, and iatrogenic endometriosis (i.e., extragonadal endometriosis), suggesting that driver mutations of oncogenes are likely to exist in RSEACs [27,28,29,30,31,32,33,34,35]. This evidence concerns the gene PIK3CA and endometriosis.