Also, the knocking out of heat shock factor-1, which reversed obese phenotype and a propensity for formation of atherosclerotic lesions in mice depleted of LDL receptors, was associated with the up-regulation of P-gp expression in the liver [25], and ABCB1 was one of the target genes recently identified in a search for compounds active against liver fibrosis with an integrated bioinformatics analysis [26]. This evidence concerns the gene LDLR and Hepatic fibrosis.