While the effect of PNPLA3 I148M on hepatic lipid homeostasis and NAFLD is being thoroughly studied, its association with serum lipids is much less examined; a small number of reports have suggested association of the PNPLA3 148M allele with decreased serum TG levels, in individuals with impaired glucose regulation [7], in the obese [8], and in patients with gallstones [9]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.