Despite our in-silico analysis of the METABRIC dataset did not provide a positive correlation between the expression of S100A7 and IGF/IGF-1R in the examined cohort of patients (data not shown), such discrepancy could be due to intrinsic limits of the gene expression methodologies used, as well as to the relative contribution of the multiple cellular component that constitute the breast tumor samples (cancer associated fibroblasts, macrophages, adipocytes, immune and endothelial cells). This evidence concerns the gene IGF1 and cancer.