STAT3 and breast cancer: In the aforementioned study, the authors showed that the blockade of both STAT3 phosphorylation by the use of a STAT3 Y705F mutant construct as well as STAT3 transactivation capacity are implicated in the up-regulation of S100A7 by Oncostatin-M and IL-6 in BC cells (27), thus corroborating the direct and pivotal role played by STAT3 in the regulation of S100A7 expression.