FNDC5 and obesity due to melanocortin 4 receptor deficiency: However, voluntary exercise by means of wheel running reversed these inflammatory and unfavorable alterations associated with increased adiposity due to HFD via mechanisms involving the improvement in colonic blood flow, restoration of plasma irisin levels as well as attenuation of colonic expression of mRNA of proinflammatory biomarkers, to some extent confirming and further extending our previous observation in exercising mice fed diet-induced obesity [9].