SOD2 and colitis: Similarly to the mRNA expression of SOD2, which was markedly elevated when IAP was co-applied in mice fed a HFD subjected to physical activity (p < 0.05) (Figure 4, right upper panel), the expression of GPx in exercising mice fed an SD and treated with IAP was significantly increased as compared to the respective values for the mRNA expression recorded in sedentary SD mice with colitis.