NR1I3 and ulcerative colitis: When directly comparing fat-1 EtOH + LPS vs. WT EtOH + LPS-treated mice, we found an increase in the expression of xenobiotic metabolism genes in fat-1 mice, including Cyp2b10, Cyp3a11, and Nr1i3. Cyp2b10 and Cyp3a11, both of which are target genes for Nr1i3, are decreased in expression in ulcerative colitis [35].