Therefore, blocking proinflammatory mediators (via inhibition of IL-1, IL-6, IFNs, TNF, GM-CSF), signaling pathways (JAK inhibitors) and lymphocytes functions (anti-CD20) may reduce cytokine storm and potentially save patients from developing acute respiratory distress syndrome (ARDS) or severe organ damage [183]. This evidence concerns the gene IL1B and acute respiratory distress syndrome.