To elucidate the impact of OSCC HLA-I/APM expression on the immune cell repertoire, the HLA-I HC and/or β2-m expression data were correlated to the frequency and the composition of intra-tumoral T cell subpopulations recently acquired by multispectral imaging within the same sample collective [32] and to the UICC tumor stages. This evidence concerns the gene ANPEP and neoplasm.