In the Preliminary Pan-Cancer Dataset, we sorted tumor samples as having WT-TP53 or any of the 15 most common hot-spot mutants (Mut-p53) and found that in tumors with Mut-TP53, the level of p53 mRNA positively correlates with NOX4 mRNA (ρ = 0.23), whereas WT-TP53 mRNA negatively correlates with NOX4 mRNA (ρ = −0.2, Figure 3). The gene discussed is TP53; the disease is cancer.