In tumor samples with Mut-TP53, NOX4 overexpression is positively correlated with proliferation markers such as proliferating cell nuclear antigen (PCNA) and cyclin-dependent kinase 1 (CDK1, Figure 8A), and negatively correlated with apoptosis-related markers such as Bcl-associated agonist of cell death (BAD), caspase 9 (CASP9), tyrosine-protein kinase ABL1 (ABL1), and TP53-binding protein 1 (TP53BP1) (Figure 8B). The gene discussed is CASP9; the disease is neoplasm.