ALK and cancer: Tyrosine kinase fusions that contain kinase-encoding genes, such as ALK, ROS1, RET, FGFR1/2/3 and NTRK1, have been detected in various types of cancer, including glioblastoma, melanoma, and carcinomas of head and neck, breast, lung, prostate, bladder, and thyroid gland [12,40,42,43].