Most of the results are derived from studies of mouse colon adenocarcinoma C26 model of cachexia, which since the 1990s suggest a role of IL-1 and IL-6 production-associated signaling pathways, as well as the intercellular interactions between IL-1R-expressing tumor cells and host-derived macrophages, hence the participation of the TME in CC [53,72,88]. This evidence concerns the gene IL6 and neoplasm.