HIF1A and neoplasm: Further studies confirmed higher tumor expression and plasma levels of IL-8, TGF-β1, and TGF-β3, as well as showed other factors’ increases (e.g., epidermal growth factor (EGF), GM-CSF, IFN-α, TGF-β2, and HIF-1α) in the tumor and serum of CRC cachectic patients.