Among the chemokines produced, CXCL8/IL-8 secreted by a subpopulation of AT derived from stromal cells intensifies tumor invasion and growth of cancer cells via phosphatidylinositol 3 kinase (PI3K), Janus kinase/signal transducer and activator of transcription protein 3 (JAK/STAT3), as well as mitogen-activated protein kinase (MAPK) (originally called extracellular signal-regulated kinase (ERK) or the Ras-Raf-MEK-ERK) pathways [125]. This evidence concerns the gene STAT3 and cancer.