According to authors, tumor remodeling through TGF-β pathway activation in CRC-associated cachexia resulted in intratumoral inflammatory response, further causing the onset of fibrosis, transdifferentiation of TME fibroblasts to myofibroblasts, and an imbalance in inflammatory cytokine profile, all responsible for progression of the CRC [30]. This evidence concerns the gene TGFB1 and neoplasm.