There were 39 genes involved in multiple pathways (Figure 4, Table S2), of which AURKB, HDAC2, PLK1, CENPA, CHEK1, CHEK2, RB1, CCNA2, and MDM2 were included in at least three pathways that are important for tumor proliferation and maintenance specific to ESR1-CCDC170 fusion-positive BRCA patients. The gene discussed is MDM2; the disease is neoplasm.