The IGF-1 Ec peptide, also known as mechano-growth factor (MGF), is up-regulated in exercised and damaged muscles, plays a neuroprotective role against ischemia and contributes to the actions of IGF-1 to improve cardiac function and activate resident stem cell populations [8,9,10,11,12,13,14,15]. The gene discussed is IGF1; the disease is ischemia.