Although the presented data do not provide unambiguous insights into the MIA-induced alterations underlying differential behavioural status in the PPI test, they give important input indicating that the changes generated in the late period of gestation may go beyond the role of the altered CX3CL1-CX3CR1 axis and microglial trajectory in the development and manifestation of behavioural deficits in adulthood following the “two-hit” hypothesis of schizophrenia. This evidence concerns the gene CX3CR1 and schizophrenia.