Moreover, Wnt-11 leads to neuroendocrine differentiation of different prostate cancer cell lines [22,36] and orchestrates many proteins, including PKC, JNK, NF-κB, Rho, PKA, PI3K, and crosstalk between Wnt-11 and TGF-β was demonstrated [37]. Here, MAPK8 is linked to Familial prostate cancer.