After confirming a strong atherosclerotic phenotype in the HF-fed mice, we determined the mRNA expressions of the orthodox isoforms, AQP1 and AQP5, and of the aquaglyceroporins AQP3, AQP7, and AQP9, in different metabolic tissues (BAT, WAT, and liver). The gene discussed is AQP5; the disease is hydrops fetalis.