FLNC and skeletal muscle disorder: Unlike histological findings in other cardiomyopathies, Valdes-Mas et al. also reported the formation of large mutated filamin C protein aggregates (in patients in vivo and in cell culture expressing mutated FLNC variants in vitro) as well as myofibril disarray and fibrosis, but again in the absence of overt skeletal myopathy [36].