This finding was confirmed in other work that investigated a broad range of lysosomal proteins in CSF samples from living AD patients and found no variations in diverse cathepsin forms (A, B, D, and L); however, the study did find altered expression for five other lysosomal proteins in the AD samples: early endosomal antigen 1 (EEA1), LAMP1, LAMP2, RAB3, and RAB7 [113]. This evidence concerns the gene CTSS and Alzheimer disease.