Although there is still no accepted ubiquitary definition of progression on ADT, the Prostate Cancer World Group 3 (PCWG3) consensus has unveiled that the evidence of a 25% increase from the nadir PSA value (in light of a starting PSA level of 1 ng/mL and with a minimum rise of 2 ng/mL), may indicate biochemical relapse, considering castrate levels of testosterone (<50 ng/mL) [9,10]. This evidence concerns the gene KLK3 and Familial prostate cancer.