ELOVL4 and macular degeneration: Considering the different tissue-specific disorders caused by the different ELOVL4 mutations, it is possible that mutations in ELOVL4 that do not substantially affect VLC-PUFA synthesis may not impact the levels of VLC-PUFA in the retina to an extent that would cause retinal degeneration as seen in patients with SCA34 who have no reported macular degeneration pathology.