ELOVL4 and age: In line with the essential role of VLC-PUFA in retinal function, the report by Donato et al. (34) that SNP in the human ELOVL4 promoter causes STGD3 suggests that loss of ELOVL4 enzymatic activity, and therefore a decrease in VLC-FA products, could cause an age-related decline in visual function, RPE atrophy, and photoreceptor death.