PRKAA1 and Parkinson disease: 2006; Gwinn et al. 2008; Kalender et al. 2010; Wong et al. 2013). AMPKα1 deficiency impairs autophagy which leads to monocyte differentiation and decrease monocyte/macro-phage survival (Zhang et al. 2017). Furthermore, increasing p-AMPK can activate autophagy and rescue SHSY-5Y cells degeneration in PD model (Gong et al. 2016). Previous studies showed that the activation of AMPK was significantly decreased during aging (Cai et al. 2020; Lin et al. 2020).