The woman with preeclampsia and cerebral edema demonstrated increased CSF concentrations of all cerebral biomarkers S100B, NSE, NfL and tau compared to all other women in the study (1.3 vs 0.9 ug/L, 10.6 vs 6.9 ug/L, 591 vs 367.5 ng/ml and 284 vs 247 ng/ml respectively) and increased circulating concentrations of S100B, NfL and tau compared to all other women in the study (0.14 vs 0.06 ug/L, 13.0 vs 6.8 ug/L and 234.7 vs 2.9 ng/ml respectively) but no statistical analyses were possible due to that only one case presented with cerebral edema. This evidence concerns the gene ENO2 and brain edema.