NOTCH2 and obstructive sleep apnea syndrome: A non-synonymous SNV, p.Asp456Tyr, was found in exon 8 of NOTCH2 (ENSCAFT00000016889.4) of the Sheepdog metastatic lesion; this mutation has not been reported in the COSMIC database (accessed 9-Jul-2019) but has been reported in a metastatic canine OSA lesion [15].