HLA-C and cancer: Our previous analysis also indicated weaker HLA binding affinities in a set of in silico generated peptides generated from cancer driver genes, questioning the interpretation from 2 other studies that attributed similar HLA affinity alterations to MHC-I and MHC-II genotype restrictions of the oncogenic mutational landscape (i.e. driver mutations only occur when they are not presentable by the underlying MHC genotype) [21,22].