FAS and Down syndrome: Many of them were members of protein families implicated in circuit assembly, such as Beaten Path (beat), Down Syndrome Cell Adhesion Molecule (Dscam), Fasciclin (Fas), Netrin (Net), Roundabout (robo), Defective Proboscis Extension Response (Dpr), and Semaphorin (Sema; Figure 8—figure supplements 1–3; Kolodkin and Tessier-Lavigne, 2011; Sanes and Zipursky, 2020), suggesting that these differentially expressed CSMs could regulate ORN wiring.