For example, approximately 1% of individuals of Ashkenazi Jewish decent have a pathogenic germline BRCA2 variant (c.6174delT) that is associated with a 10-fold increased risk of pancreatic cancer, as well as an increased risk of other cancers including cancers of the breast, ovary, and prostate [25–30]. The gene discussed is BRCA2; the disease is familial pancreatic carcinoma.