Furthermore, chemokines IL-8, CCL2 and CCL4 have been shown to be especially relevant in aggressive PD subtypes such in PD-LRRK2 patients with diffuse/malignant PD [17], and in GBA-PD, where IL-8 was correlated with higher cognitive deficits [27]. The gene discussed is CXCL8; the disease is Cognitive impairment.