RELB and Atrophy: In accordance with and in response to the multiorgan inflammation (Weih et al., 1995; O’Sullivan et al., 2018), thymic atrophy as measured by the reduced number of total thymocytes was detected in relB-deficient mice mildly at 1 wk old and moderately at 2 wk old (Fig. 4 F and Fig. S5, A–C).